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Renal sodium-glucose transport: role in diabetes mellitus and potential clinical implications
Regarding Diabetes mellitus management, the effect of metformin, a classic anti-diabetic drug, on epilepsy is controversial: on the one hand, studies have confirmed that it, as an AMPK agonist, activates thalamic AMP-activated protein kinase, thereby enhancing metabotropic GABAB receptor function and ultimately promoting absence epileptic seizures (95)
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